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RECENT ADVANCES IN PHARMACEUTICAL CHEMISTRY—REVIEW II HISTAMINE H 2 ‐RECEPTOR ANTAGONISTS
Author(s) -
Lee R. M.,
McDowall R. D.
Publication year - 1986
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1986.tb00868.x
Subject(s) - cimetidine , ranitidine , histamine , pharmacology , histamine h2 receptor , chemistry , histamine antagonists , histamine receptor , histamine h1 antagonists , stereochemistry , receptor , medicine , combinatorial chemistry , biochemistry , antagonist
SUMMARY The concept of histamine receptors is outlined and the rationale for the synthesis of H 2 ‐antagonists presented. Structure‐activity relationships among these compounds are described and aspects of absorption, distribution and elimination discussed with particular reference to cimetidine and ranitidine. Oxmetidine, lupitidine and loxtidine are also considered. Methods for the analysis of these drugs in body fluids are presented followed by a discussion of their toxicology. Volunteer and patient studies are also surveyed.