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ETHYLENE CHLOROHYDRIN DETERMINATION IN ETHYLENE OXIDE STERILIZED POLYVINYL CHLORIDE TUBING
Author(s) -
Merckx J.,
Kinget R.
Publication year - 1986
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1986.tb00864.x
Subject(s) - polyvinyl chloride , ethylene oxide , ethylene , chemistry , chloride , extraction (chemistry) , chromatography , poly ethylene , gas chromatography , organic chemistry , polymer , copolymer , catalysis
SUMMARY A convenient rapid gas‐chromatographic method is described for the quantitative determination of ethylene chlorohydrin. The method reported herein extracts the ethylene chlorohydrin with water. The method is simple and offers advantages since no elaborate and expensive gas extraction apparatus is required. The ethylene chlorohydrin levels in five different sterilized polyvinyl chloride samples were found to vary between 5 and 25 ppm. The effect of resterilization with ethylene oxide was investigated and was found to produce less ethylene chlorohydrin.