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DETERMINATION OF IN VIVO CONCENTRATION‐TIME PROFILES OF CHLORHEXIDINE AND NOXYTHIOLIN BLADDER IRRIGATIONS
Author(s) -
Cottrell W. N.,
Fitzpatrick R. W.
Publication year - 1986
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1986.tb00861.x
Subject(s) - chlorhexidine , irrigation , zoology , minimum inhibitory concentration , in vivo , medicine , chemistry , chromatography , dentistry , agronomy , antibiotics , biology , microbiology and biotechnology , biochemistry
SUMMARY The in vivo concentration‐time profiles of chlorhexidine and noxythiolin bladder irrigations were determined by utilizing high‐performance liquid chromatography techniques following a once daily irrigation. A total of 14 chlorhexidine irrigations established a mean concentration of 0.006% w/v, 2–3 h post irrigation. A total of 12 noxythiolin irrigations established a mean concentration of 0·266% w/v, 2–3 h post irrigation, which correlated to a mean formaldehyde concentration of 0·0119% w/v at 2–3 h, as estimated from N‐methylthiourea. For both solutions the minimum inhibitory concentration was exceeded for up to 5 h post irrigation, which is sufficient contact time to establish a total kill, thus indicating the possibility that a once daily irrigation may be appropriate in asymptomatic bacteriuria which utilizes either chlorhexidine or noxythiolin.