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QUANTIFICATION OF ETHYLENE CHLOROHYDRIN AND ETHYLENE GLYCOL AS POTENTIAL REACTION PRODUCTS IN GAS‐STERILIZED MEDICAL‐GRADE PLASTICS
Author(s) -
Rudder D. De,
Graeve E. De,
Severen R. Van,
Braeckman P.
Publication year - 1986
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1986.tb00836.x
Subject(s) - ethylene glycol , ethylene oxide , solvent , ethylene , chemistry , gas chromatography , detection limit , chromatography , organic chemistry , catalysis , copolymer , polymer
A gas chromatographic procedure is described for the quantitative determinations of ethylene chlorohydrin and ethylene glycol in disposable medical‐grade plastics. Both components are isolated by solvent extraction. The lower limit of detection is 1 p.p.m. of ethylene chlorohydrin and 2 p.p.m. of ethylene glycol. Propylene glycol is used as an internal standard. Ethylene oxide residues have to be removed prior to the assay.