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AN INVESTIGATION OF THE IN VITRO ANTI‐BACTERIAL ACTIVITY OF NOXYTHIOLIN AGAINST 1,000 PATHOGENIC BACTERIAL ISOLATES
Author(s) -
Ashley K. C.,
Myerthall D. L.
Publication year - 1986
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1986.tb00832.x
Subject(s) - minimum inhibitory concentration , agar , microbiology and biotechnology , in vitro , gram , agar plate , liter , bacteria , chemistry , biology , antibiotics , biochemistry , genetics , endocrinology
SUMMARY The susceptibility of 1,000 recent bacterial isolates to noxythiolin was determined by the disc susceptibility method. No Gram‐positive strains were resistant to this method but 56 (5.6%) of Gram‐negative strains gave zones of inhibition of 12 mm diameter or less. The minimum inhibitory concentration (MIC) of the latter were determined by the agar incorporation method. No strains had MIC values greater than 4096 mg/litre. Since concentrations of 50,000 mg/litre can be used for topical treatment, these organisms may be considered susceptible.