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A COMPARISON OF THE ANTIMICROBIAL ACTIVITIES OF NOXYTHIOLIN AND FORMALDEHYDE SOLUTIONS
Author(s) -
Gorman S. P.,
McCafferty D. F.,
Woolfson A. D.,
Anderson Lesley
Publication year - 1985
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1985.tb01132.x
Subject(s) - formaldehyde , antimicrobial , chemistry , microbiology and biotechnology , polarography , food science , nuclear chemistry , biology , biochemistry , inorganic chemistry
SUMMARY The availability of a rapid and highly specific polarographic method of analysis for formaldehyde enabled investigation of the rate of formaldehyde release from noxythiolin solutions and actual concentrations of formaldehyde in solutions during clinical use and storage. The antimicrobial activity of noxythiolin solutions, equivalent pure formaldehyde solutions and N‐methylthiourea individually or in combination was examined against standard bacteriological strains and clinical isolates. Several interesting observations were made. Clinical isolates were found to be relatively susceptible to noxythiolin in contrast to laboratory strains. The growth phase of the organism radically affects activity, early exponential phase cells being susceptible to 1.0% noxythiolin. Levels of formaldehyde detected in fresh noxythiolin solutions are extremely low and would not appear to be solely responsible for the antimicrobial activity observed.