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THE EFFECTIVENESS OF DRUG LEVEL MONITORING AND PHARMACOKINETICS IN INDIVIDUALIZING THEOPHYLLINE THERAPY
Author(s) -
Fitzpatrick R. W.,
MossBarclay C.
Publication year - 1985
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1985.tb00925.x
Subject(s) - theophylline , pharmacokinetics , therapeutic index , medicine , therapeutic drug monitoring , drug , pharmacology , population , bronchodilator , asthma , environmental health
A pharmacokinetic method for individualizing theophylline dosage is described. The method was shown to be reliable and accurate, and maintained significantly more patients within the optimum therapeutic range when compared with conventional regimens. The study also showed that when conventional dosage regimens are used, a large proportion of patients exhibit theophylline levels well below the optimum therapeutic range. Population pharmacokinetic data for theophylline and the effect of congestive heart failure on its clearance are also presented.