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DRUG TARGETING—CURRENT ASPECTS AND FUTURE PROSPECTS
Author(s) -
Pouton C. W.
Publication year - 1985
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1985.tb00715.x
Subject(s) - monoclonal antibody , in vivo , drug carrier , targeted drug delivery , medicine , drug , drug delivery , pharmacology , mechanism of action , monoclonal , in vitro , antibody , cancer research , chemistry , immunology , nanotechnology , biology , materials science , biochemistry , microbiology and biotechnology
A variety of materials have been suggested as carriers for the delivery of drugs to specific sites of action. Drugs may be covalently bound to carriers or physically trapped within particulate carriers. Likely mechanisms of action of targeting agents are described. The results of in vitro and in vivo experiments are reviewed and the prospective clinical uses of each type of carrier are discussed. In particular, monoclonal antibodies are promising agents for the targeting of cytotoxic agents to malignant cells. Radiolabelled monoclonal antibodies are likely to develop as agents for the radio‐imaging of tumours which will prove useful in the diagnosis and treatment of cancer.