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STABILITY OF NOXYTHOLIN SOLUTIONS STORED IN PLASTIC AND GLASS CONTAINERS
Author(s) -
McCafferty D. F.,
Furness K.,
Anderson L.
Publication year - 1984
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1984.tb01082.x
Subject(s) - polypropylene , degradation (telecommunications) , materials science , formaldehyde , composite material , chemistry , organic chemistry , computer science , telecommunications
SUMMARY The stability of two different concentrations (1% and 2.5% w/v) of noxythiolin (Noxyfiex and Noxyflex S) stored at a variety of temperatures (4, 20 and 37°) in both plastic and glass bottles has been examined over a period of 40 days. During this period noxythiolin solutions held at 20d̀ and 37° attained equilibrium (K = 0.285\;pm0.015 mol/1). Neither noxythiolin nor its degradation products (N‐methylthiourea and formaldehyde) were absorbed by the plastic (polypropylene) containers used. Therefore, noxythiolin solutions can be stored in certain plastic (polypropylene) containers under the same conditions as recommended for glass bottles.