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FACTORS CONTRIBUTING TO VARIABILITY IN DRUG PHARMACOKINETICS. I. ABSORPTION
Author(s) -
Welling Peter G.,
Tse Francis L. S.
Publication year - 1984
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1984.tb01075.x
Subject(s) - drug , pharmacokinetics , absorption (acoustics) , pharmacology , distribution (mathematics) , medicine , drug metabolism , mathematics , mathematical analysis , physics , acoustics
SUMMARY Apart from the physical and chemical properties of a drug, and also the dosage form in which it is presented, many other factors may affect the absorption of orally administered compounds and give rise to variable systemic availability. Three such factors, gastrointestinal (GI) disease, drug‐drug interactions, and drug‐food interactions are considered here. Although information regarding these factors, particularly GI disease, is scarce and sometimes conflicting, it is clear that they may give rise to variable drug absorption. The wide spectrum of effects on different drugs precludes the application of general rules and guidelines in drug therapy in most cases. Drugs, dosage forms, and various interactions should be considered individually. Also the types of interactions described in this review must be combined with other factors to be discussed later in this series when considering the influence of variable absorption, distribution, metabolism, and excretion on durg pharmacokinetics and clinical efficacy.