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NOXYTHIOLIN—HIGH‐PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY AND STABILITY
Author(s) -
Irwin W. J.,
Po A. Li Wan,
Stephens J. S.
Publication year - 1984
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1984.tb00917.x
Subject(s) - chromatography , chemistry
SUMMARY A rapid stability‐indicating high‐performance liquid chromatographic assay for noxythiolin has been developed and its application to the determination of the shelf‐life of solid and solution forms is illustrated. Kinetic models which describe the degradation profile have been evaluated and concentrated solutions are modelled by a A = B + C system whereas more dilute solutions approximate to the A = B or limiting first‐order case.