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FATE OF CHLORBUTOL DURING STORAGE IN POLYETHYLENE DROPPER CONTAINERS AND SIMULATED PATIENT USE
Author(s) -
Holdsworth D. G.,
Roberts M. S.,
Polack A. E.
Publication year - 1984
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1984.tb00916.x
Subject(s) - polyethylene , aqueous solution , container (type theory) , sorption , permeation , materials science , chemistry , chemical engineering , chromatography , composite material , organic chemistry , adsorption , engineering , biochemistry , membrane
SUMMARY The disappearance of chlorbutol from aqueous solutions stored in polyethylene containers under various experimental and simulated patient use conditions is described. Chlorbutol is lost by sorption into the container wall, container insert and by permeation into the external environment. The extent of chlerbutol loss from solution and uptake by the container components is dependent on temperature, chlorbutol concentration and the closure used. Aqueous chlorbutol solutions stored in the polyethylene container evaluated have a predicted shelf‐life (time for 10% loss) of about 4 months at 25d̀C and 8 months at 20d̀C. Negligible loss is found during simulated patient use over 1 month.