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STABILITY OF CEFSULODIN IN AQUEOUS BUFFERED SOLUTIONS AND SOME INTRAVENOUS ADMIXTURES
Author(s) -
Gupta V. Das,
Stewart Kenneth R.
Publication year - 1984
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1984.tb00915.x
Subject(s) - cefsulodin , chemistry , chromatography , aqueous solution , ionic strength , organic chemistry , genetics , bacteria , ceftazidime , pseudomonas aeruginosa , biology
SUMMARY The stability of cefsulodin in aqueous solutions of various pH values, buffer concentrations, ionic strengths and intravenous admixtures were studied using a stability‐indicating high‐pressure liquid chromatography method. The pH range of optimum stability was determined to be 3·2–5·7. Cefsulodin was more stable on the acidic and less on the alkaline side as compared with most of the other cephalosporins such as cefoxitin (pH range of optimum stability ˜ 4–7). In 5% dextrose and 0·9% sodium chloride injection, cefsulodin was stable (at least 90% potent) for about 1, 17 and at least 60 days at 24d̀, 5d̀ and ‐10d̀C, respectively.