Premium
STORAGE OF MIXTURES FOR TOTAL PARENTERAL NUTRITION—LONG‐TERM STABILITY OF A TOTAL PARENTERAL NUTRITION MIXTURE
Author(s) -
Nordfjeld K.,
Rasmussen M.,
Jensen V. GaunØ
Publication year - 1983
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1983.tb01106.x
Subject(s) - parenteral nutrition , term (time) , medicine , intensive care medicine , physics , quantum mechanics
SUMMARY A TPN mixture containing amino acids, dextrose, electrolytes, and trace elements was analysed for chemical stability during storage at 4° for 6 months. Dextrose, electrolytes, and trace elements appeared to be stable during the storage period. However, this study established that some amino acids were not stable for more than 2 months. After 6 months, the amino acids except tyrosine, lysine, and histidine were degraded by more than 10%. The most pronounced degradation was seen with alanine, proline, threonine, methionine, glycine, and arginine. Tryptophan was, in spite of the presence of bisulphite, one of the more stable amino acids. Further investigations are needed to identify the degradation products. pH and colour of the solution remained unchanged during the study and no precipitation was observed.