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THE EFFECT OF LOW DENSITY POLYETHYLENE CONTAINERS ON SOME HOSPITAL‐MANUFACTURED EYEDROP FORMULATIONS II. INHIBITION OF THE SORPTION OF PHENYLMERCURIC ACETATE
Author(s) -
Aspinall J. E.,
Duffy T. D.,
Taylor C. G.
Publication year - 1983
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1983.tb01101.x
Subject(s) - sorption , chemistry , preservative , benzalkonium chloride , chloride , polyethylene , nuclear chemistry , chromatography , hydrochloride , polyvinyl chloride , phosphate , organic chemistry , adsorption
SUMMARY The presence of phosphate ions in solutions of phenylmercuric acetate inhibits the sorption of the preservative by low‐density polyethylene eyedrop bottles. The extent to which sorption is inhibited depends upon the concentration of phosphate but does not appear to be temperature dependent. Phenylmercuric preservatives react with chloride ion to produce insoluble phenylmercuric chloride and should therefore not be used to preserve eyedrops containing chloride or hydrochloride salts.