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ANALYSIS AND MICROBIOLOGICAL STABILITY OF AN ISOSORBIDE 50% MIXTURE
Author(s) -
Brown A. F.,
Fisher B.,
Harvey D. A.,
Hoddinott D. J.
Publication year - 1983
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1983.tb01056.x
Subject(s) - isosorbide , antimicrobial , sorbitol , chromatography , clinical significance , medicine , chemistry , organic chemistry
SUMMARY Isosorbide mixture containing 50% w/v isosorbide and 5% w/v sorbitol is used in the treatment of hydrocephalus. The G.L.C. analysis of the mixture is described and its antimicrobial properties investigated. Results for the determination of lead in the mixture are given and the significance of the levels discussed with relevance to the treatment of infants.