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THE ROLE OF α‐ADRENOCEPTOR BLOCKADE IN THE TREATMENT OF HYPERTENSION
Author(s) -
Abrams S. M. L.,
Turner P.
Publication year - 1983
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1983.tb01048.x
Subject(s) - medicine , blockade , blocking (statistics) , postsynaptic potential , pharmacology , receptor , statistics , mathematics
SUMMARY Early attempts to use α‐adrenoceptor blockers in the treatment of hypertension were unsuccessful due to a high prevalance of side‐effects. Now that the concept of two α‐adrenoceptors, α 1 and α 2 has been investigated, specific α, postsynaptic adrenoceptor blocking drugs have become available to treat hypertension. Their efficacy, tolerance and acceptability are discussed, and indications for their usage suggested.