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THE COMPARATIVE BIOAVAILABILITY OF SLOW RELEASE ORAL THEOPHYLLINE PREPARATIONS
Author(s) -
Edwards C.,
Cope A. S.,
Jackson A. H.,
Purkiss R.
Publication year - 1983
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1983.tb00897.x
Subject(s) - theophylline , bioavailability , plasma concentration , pharmacokinetics , pharmacology , stomach , oral administration , dosage form , medicine , bronchodilator , chemistry , oral dose , asthma
SUMMARY Plasma concentrations of theophylline were determined in healthy volunteers following a single oral dose of six slow release preparations, immediately following a standard breakfast. There were no significant differences between the different preparations. The time taken to reach maximum plasma concentration, t max , was found to be longer than in previous studies in which the drug was administered on an empty stomach.