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THE STABILITY OF ADRENALINE OPHTHALMIC SOLUTIONS ON STERILIZATION AND STORAGE
Author(s) -
Sixsmith D. G.,
Watkins W. M.,
Kokwaro G. O.
Publication year - 1982
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1982.tb01024.x
Subject(s) - sterilization (economics) , chemistry , chromatography , monetary economics , economics , foreign exchange market , foreign exchange
SUMMARY The stability of adrenaline ophthalmic solutions, at pH 5·8 and 7·4, to sterilization and storage conditions has been studied. Solutions sterilized by filtration or heating at 98d̀C for 30 min showed no detectable degradation at either pH value, whilst sterilization at higher temperatures resulted in losses of up to 30%. Total degradation increased with increasing sterilization temperature at both pH values.