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MOLECULAR WEIGHT AND THERAPEUTIC DOSE OF DRUG
Author(s) -
Lien Eric J.
Publication year - 1982
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1982.tb01009.x
Subject(s) - potency , drug , pharmacology , chemistry , medicine , biochemistry , in vitro
SUMMARY This report presents statistically significant empirical correlations between the potency (as expressed by log 1/C) and the molecular weight (log M.W.) of water soluble vitamins, various centrally acting drugs and anticancer agents. The implications of these correlations are discussed in terms of protein binding, renal elimination and drug‐receptor binding. The limitations of this type of correlation are also presented.