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PHARMACOKINETIC CONSIDERATIONS IN THE HAEMODIALYSIS OF DRUGS
Author(s) -
Parker Peter R.,
Parker William A.
Publication year - 1982
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1982.tb01008.x
Subject(s) - pharmacokinetics , drug , medicine , pharmacology , volume of distribution , dialysis , intensive care medicine , safer , computer science , computer security
SUMMARY Clinical pharmacists can deliver safer and more efficacious drug therapy to end‐stage renal patients with knowledge and application of the pharmacokinetics of haemodialysis. The physical, chemical and pharmacokinetic properties of a drug will determine its degree of dialysability. These properties include water solubility, molecular weight, protein binding, volume of distribution, and the fraction, route and rate of drug elimination. Various dialysis‐induced metabolic alterations must also be considered. With an understanding of these factors, the pharmacist can determine whether dosage adjustments are necessary and, if so, make the required calculations accurately.