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PARTITION COEFFICIENTS OF SOME AROMATIC ALCOHOLS IN AN n ‐HEPTANE/WATER SYSTEM AND THEIR RELATIONSHIP TO MINIMUM INHIBITORY CONCENTRATION AGAINST PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS
Author(s) -
Wilson J. R. J.,
Lyall J.,
McBride R. J.,
Murray J. B.,
Smith G.
Publication year - 1981
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1981.tb00888.x
Subject(s) - heptane , pseudomonas aeruginosa , partition coefficient , minimum inhibitory concentration , staphylococcus aureus , chemistry , inhibitory postsynaptic potential , partition (number theory) , microbiology and biotechnology , organic chemistry , biology , mathematics , bacteria , antimicrobial , combinatorics , genetics , neuroscience
SUMMARY The partition coefficients of the homologous series of aromatic alcohols were determined in an n ‐heptane/water system. The minimum inhibitory concentrations of benzyl alcohol, 2‐phenylethanol, 3‐phenylpropanol, 4‐phenylbutanol and 5‐phenylpentanol were elucidated against Pseudomonas aeruginosa and Staphylococcus aureus. The linear relationship logl/C = a log P + b postulated by Hansch was found to apply.