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A COMPARISON OF PHENYLPROPANOL (0.5%) WITH CHLOROFORM (0.25%) AND AN ADMIXTURE OF METHYL HYDROXYBENZOATE (0.06%) AND PROPYL HYDROXYBENZOATE (0.03%) AS PRESERVATIVES IN LIQUID MEDICINES
Author(s) -
Goodall Jane A.,
Lyall J.,
McBride R. J.,
Murray J. B.,
Smith G.
Publication year - 1980
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1980.tb00976.x
Subject(s) - hydroxybenzoate , chloroform , preservative , chemistry , chromatography , organic chemistry
The effectiveness as a preservative in liquid medicines of phenylpropanol 0.5%, chloroform 0.25% and an admixture of methyl hydroxybenzoate 0.06% with propyl hydroxybenzoate 0.03% has been evaluated by determination of sterilization times. Phenylpropanol was as effective as chloroform against Escherichia coli and Staphylococcus aureus ; in some mixtures phenylpropanol was more rapidly bactericidal than was chloroform against Pseudomonas aeruginosa. The admixture of hydroxybenzoates was a poor preservative. Problems in the preservation of paediatric chalk mixture were solved by the use of sterilized chalk and the replacement of tragacanth by derivatives of starch.