Premium
STRUCTURE SIDE‐EFFECT SORTING OF DRUGS
Author(s) -
Lien E. J.,
Lien L. L.
Publication year - 1980
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1980.tb00967.x
Subject(s) - polymyxin , medicine , drug , antibiotics , analgesic , pharmacology , rheumatoid arthritis , intensive care medicine , cephalosporin , chemistry , biochemistry
A literature survey has been done on drug‐ and chemical‐associated nephrotoxicities. Among the 1450 entries examined about 225 (15.5%) have been associated with various types of renal toxicities. These include heavy metals, halogenated organic solvents and general anaesthetics, glycols, analgesics and non‐steroidal anti‐inflammatory agents (prostaglandin synthetase inhibitors), sulphonamides, various antibiotics (aminoglycosides, penicillins and cephalosporins, tetracyclines. amphotericin B. polymyxins and vancomycin), radiographic contrast media and others. Common structural features and possible mechanisms involved in these nephrotoxins are discussed. It is hoped that appropriate measures and advice will be given by physicians and pharmacists to patients taking any of these drugs, especially if predisposing factors are present or prolonged administration of these drugs is needed for the control of chronic diseases (such as analgesic and non‐steroidal anti‐inflammatory agents in controlling rheumatoid arthritis).