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REVIEW OF RECENT STUDIES ON CONTROL OF AMINOGLYCOSIDE ANTIBIOTIC THERAPY
Author(s) -
Davey P. G.,
Gonda I.,
Harpur E. S.,
Scott D. K.
Publication year - 1980
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1980.tb00962.x
Subject(s) - aminoglycoside , pharmacokinetics , medicine , intensive care medicine , toxicity , antibiotics , renal function , therapeutic index , pharmacology , drug , biology , microbiology and biotechnology
This article reviews the methods for determination of individual dosage regimens for patients receiving aminoglycoside therapy and their value with respect to efficacy and toxicity. Although a large volume of literature has been devoted to dose adjustment in patients with renal failure, the majority of patients requiring aminoglycoside treatment have normal renal function. Evidence is presented that the large variation in aminoglycoside pharmacokinetics necessitates some degree of blood sampling to ensure adequate control of therapy at all levels of renal function. Aminoglycoside disposition, particularly the recent studies on tissue uptake, is discussed from the point of view of its effect on individual variations in pharmacokinetics and susceptibility to toxicity. While general recommendations for a safe and effective range of serum concentrations can be made, individual host factors play a dominant part in the success of therapy and avoidance of toxicity. The advantages and disadvantages of different methods of pharmacokinetic control are discussed. Finally, the major unsolved problems are re‐stated and suggestions made for future research.