Premium
LOSS OF CHLOROFORM FROM MAGNESIUM TRISILICATE MIXTURE UNDER SIMULATED IN‐USE CONDITIONS
Author(s) -
Purkiss Ronald
Publication year - 1977
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1977.tb00086.x
Subject(s) - magnesium , chloroform , chemistry , environmental science , mathematics , chromatography , organic chemistry
Summary Investigations were carried out under simulated in use conditions to determine the loss of chloroform from Magnesium Trisilicate Mixtures manufactured using Chloroform Water Double Strength, Chloroform Emulsion and Chloroform Spirit. Magnesium Trisilicate Mixture B.P.C. showed a loss of 33–40% of the initial chloroform content after 140 × 10 ml aliquots had been removed from a single container. Mixtures manufactured using Chloroform Spirit and Emulsion had higher initial values of chloroform content, also the chloroform remained in solution longer than in the B.P.C. mixtures. A survey of hospital manufactured Magnesium Trisilicate Mixtures showed that there are difficulties in manufacturing mixtures that contain the correct chloroform content. Mixtures from 22 hospitals were analysed of which three contained the expected concentration of chloroform.