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PHARMACOKINETIC MANAGEMENT OF STREPTOMYCIN DOSAGE
Author(s) -
Mulley B. A.,
Mallinson E. J. H.
Publication year - 1977
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1977.tb00085.x
Subject(s) - pharmacokinetics , streptomycin , volume of distribution , medicine , renal function , pharmacology , creatinine , distribution (mathematics) , mathematics , chemistry , antibiotics , mathematical analysis , biochemistry
Summary Pharmacokinetic data has been obtained for seven clinical subjects after single i.m. doses of streptomycin. An attempt has been made to relate the half‐lives found to the kidney functions of the subjects, as estimated from their serum creatinine levels, by standard published methods. A high degree of scatter was observed in the plot of the results. Further analysis of the data was attempted taking into account individual variations in the volume of distribution of the drug, which may be partly responsible for the scatter.