Premium
The effect of some formulation variables on the bioequivalence of methaqualone preparations
Author(s) -
Gunning S. R.,
Kendall M. J.,
Mitchard M.,
Stead J. A.,
Williams M. E.
Publication year - 1976
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1976.tb00065.x
Subject(s) - methaqualone , bioequivalence , bioavailability , chemistry , pharmacology , biopharmaceutics , drug , chromatography , medicine , in vitro , biochemistry , biological activity , pharmacognosy
Summary The effect of a number of formulation variables on the bioavailability of methaqualone, in the presence of diphenhydramine hydrochloride, has been examined. The formulation variables include particle size of methaqualone, excipients and method of manufacture. A reduction in drug particle size was shown to increase bioavailability in both normal and low weight subjects. The effects of other formulation variables are less well marked in the latter group of subjects than in the former. The relationship between in vitro dissolution results and the in vivo studies has been examined and the results indicate that plasma methaqualone levels are inversely proportional to body weight.