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In vitro dissolution studies on commercial ampicillin capsules
Author(s) -
SouthallEdwards G.,
Mehta A. C.,
Midcalf B.,
Hetherington C.
Publication year - 1976
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1976.tb00057.x
Subject(s) - dissolution , ampicillin , chromatography , gastric fluid , chemistry , in vitro , dissolution testing , biochemistry , antibiotics , organic chemistry , biopharmaceutics classification system
Summary The in vitro dissolution rates of ampicillin 250 mg and 500 mg capsules from different companies were measured. The dissolution in simulated gastric fluid in 20 min ranged from 80% to virtually 100% of the stated content. In water the dissolution time in this range was 30 min. Intra‐ and inter‐batch variations were found to be relatively insignificant.