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The particle size distribution of emulsions containing diazepam for intravenous use
Author(s) -
Jeppsson R. I.,
Groves M. J.,
Yalabik H. S.
Publication year - 1976
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1976.tb00055.x
Subject(s) - particle size , emulsion , particle size distribution , materials science , diazepam , particle (ecology) , chromatography , range (aeronautics) , biomedical engineering , anesthesia , chemistry , medicine , composite material , organic chemistry , oceanography , geology
Summary The particle size and distribution of size of emulsions intended for intravenous administration is critical for the safety of the patient owing to the dangers of embolism. However, methods of measuring the size are limited in accuracy in the micrometre and sub‐micrometre range. The use of a laser centrifugal photosedi‐mentometer (LCP) is described which is capable of detecting particles down to 002 m̈ m and would appear to be eminently suitable for characterizing emulsion systems in the critical size range. The instrument has been applied to a new drug vehicle containing diazepam which is based on intravenous nutritional emulsions. This emulsion was shown to have a mean particle diameter of 0–2 m̈ m, comparable with literature values for chylomicra and similar to previous experimental results on intravenous emulsions. This suggests that the drug formulation is suitable for clinical application, especially as'animal studies indicate that it has a reduced toxicity when compared to propylene glycol injection solutions.