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The stability of sulphadiazine sodium as used in admixture with intravenous infusion fluids
Author(s) -
Preskey Denise,
Kayes J. B.
Publication year - 1976
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1976.tb00047.x
Subject(s) - intravenous infusions , chromatography , intravenous fluid , chemistry , anesthesia , medicine , pharmacology
Summary An investigation has been made of the stability of sulphadiazine sodium in admixture with various infusion fluids. There was little evidence of oxidative degradation with dilution of sulphadiazine injection in normal saline, water and mannitol solution, no measurable breakdown being found under the conditions of test. Sugars (with aldehyde or ketone groups) were found to form coloured compounds with sulphadiazine sodium, the amount being dependent on temperature, concentration and type of sugar. The importance of pH in considering the solubility of sulphadiazine sodium in infusion fluids has been examined. It is concluded that dilutions of sulphadiazine sodium injection in normal saline are stable for the time of administration, but there is a danger of pH dependent precipitation if addition is made to drip chambers.