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The stability of suspensions prepared extemporaneously from solid dosage forms
Author(s) -
Brown Godson C.,
Kayes J. B.
Publication year - 1976
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.1976.tb00046.x
Subject(s) - propranolol hydrochloride , preservative , suspension (topology) , dosage form , chromatography , chemistry , shelf life , ampicillin , propranolol , medicine , mathematics , anesthesia , organic chemistry , food science , biochemistry , antibiotics , homotopy , pure mathematics
Summary In hospital practice it is sometimes necessary to prepare suspensions from solid dosage forms. A list of those in common use is presented. Whilst the manufacturer of the solid dosage form will usually supply a formula for preparing a suspension, stability data are not normally available. An investigation was therefore made into the stability of two such suspensions, propranolol hydrochloride (Inderal) and ampicillin (Penbritin). With propranolol hydrochloride suspension the preservative was inactivated and there was evidence of an increased rate of degradation, partly dependent on pH. The ampicillin suspension, at an unadjusted acid pH, was not satisfactory. Alternative formulae, with a shelf life of at least two weeks, are suggested.