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Reduction of vitamin K concentration by salivary Bifidobacterium strains and their possible nutritional competition with Porphyromonas gingivalis
Author(s) -
Hojo K.,
Nagaoka S.,
Murata S.,
Taketomo N.,
Ohshima T.,
Maeda N.
Publication year - 2007
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/j.1365-2672.2007.03436.x
Subject(s) - bifidobacterium , actinomycetaceae , bifidobacterium longum , porphyromonas gingivalis , microbiology and biotechnology , vitamin , biology , saliva , bacteroidaceae , bacteria , biochemistry , lactobacillus , genetics
Aims: To assess the possibility that bifidobacteria compete with Porphyromonas gingivalis for their mutual growth factor vitamin K. This study also examined whether salivary Bifidobacterium species decrease vitamin K concentration in the growth medium. Methods and Results: Sixty‐five strains of Bifidobacterium were obtained from 20 of 24 periodontally healthy subjects. Bifidobacterium dentium was most frequently detected in the saliva of subjects, followed by Bifidobacterium adolescentis , Bifidobacterium longum, and Bifidobacterium urinalis . The growth of most Bifidobacterium isolates, except that of B. urinalis , was stimulated by vitamin K. Moreover, the isolates were capable of decreasing vitamin K after incubation, which suggests that bifidobacteria compete with P. gingivalis for vitamin K. In a co‐culture, a representative strain – B. adolescentis S2‐1 – inhibited the growth of P. gingivalis if it was inoculated in the medium before P. gingivalis. Conclusions: B. adolescentis S2‐1 decreased vitamin K concentration and inhibited the growth of P. gingivalis by possibly competing for the growth factor. Significance and Impact of the Study: Salivary bifidobacteria may possess the potential to suppress the growth of P. gingivalis by reducing the growth factor(s) in the environment.