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In vitro antimicrobial activity of a novel propolis formulation (Actichelated propolis)
Author(s) -
Drago L.,
De Vecchi E.,
Nicola L.,
Gismondo M.R.
Publication year - 2007
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/j.1365-2672.2007.03421.x
Subject(s) - propolis , library science , clinical microbiology , medicine , traditional medicine , microbiology and biotechnology , biology , computer science
Aims: This study compared in vitro activities of Actichelated ® propolis (a multicomposite material obtained with mechano‐chemichal activation) and of a hydroalcoholic extract of propolis. Methods and Results: Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), determined by means of microdilution broth method, against five strains of Staphylococcus aureus , Streptococcus pyogenes , Haemophilus influenzae , Enterococcus spp., Escherichia coli , Proteus mirabilis and Pseudomonas aeruginosa, showed a greater potency of Actichelated ® propolis (MIC range: 0·016–4 mg flavonoids ml −1 ) in respect to the hydroalcoholic extract (MIC range: 0·08–21·4 mg flavonoids ml −1 ). Concentrations of Actichelated ® propolis active against adenovirus, influenza virus, parainfluenza virus and herpes virus type 1 were at least 10 times lower than those of the hydroalcoholic extract. Preincubation of Strep. pyogenes and H. influenzae with subinhibitory concentrations of Actichelated ® propolis (1/4 and 1/8 × MIC) significantly reduced the number of bacteria that adhered to human buccal cells. Conclusions: Actichelated ® propolis has proven to possess antibacterial and antiviral activity higher than a hydroalcoholic extract, being also able to interfere on bacterial adhesion to human oral cells. Significance and Impact of the Study: This new formulation of propolis showing better antimicrobial and physical characteristics could improve the application of propolis in respiratory tract infections.