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Antiobesity effect of trans ‐10, cis ‐12‐conjugated linoleic acid‐producing Lactobacillus plantarum PL62 on diet‐induced obese mice
Author(s) -
Lee K.,
Paek K.,
Lee H.Y.,
Park J.H.,
Lee Y.
Publication year - 2007
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/j.1365-2672.2007.03336.x
Subject(s) - conjugated linoleic acid , lactobacillus plantarum , linoleic acid , food science , adipose tissue , chemistry , lactobacillus , biochemistry , biology , lactic acid , bacteria , fermentation , fatty acid , genetics
Aims: To observe the antiobesity activity of trans ‐10, cis ‐12‐conjugated linoleic acid (CLA)‐producing lactobacillus in mice. Methods and Results: Lactobacillus plantarum PL62, which can grow in the presence of linoleic acid, was selected and studied. The culture supernatant of Lact. plantarum PL62 contained trans ‐10, cis ‐12‐conjugated linoleic acid (6·4 μ g ml −1 ), and the crude enzyme prepared from washed cells produced trans ‐10, cis ‐12 CLA (1395 μ g mg −1 protein). Lact. plantarum PL62 reduced the weights of epididymal, inguinal, mesenteric, and perirenal white adipose tissues and significantly reduced the blood levels of total glucose and body weights of mice ( P < 0·01). Conclusions: trans ‐10, cis ‐12‐CLA‐producing Lact. plantarum PL62 can exert the same antiobesity activity as trans ‐10, cis ‐12‐CLA in mice. Significance and impact of the study: trans ‐10, cis ‐12‐CLA‐producing Lactobacillus can be a replacement for CLA for obesity treatment via the continuous production of trans ‐10, cis ‐12‐CLA. The results provide a novel opportunity to develop foods with antiobesity activity.