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Transmission of Salmonella enterica serotype Typhimurium in poultry with and without antimicrobial selective pressure
Author(s) -
BauerGarland J.,
Frye J.G.,
Gray J.T.,
Berrang M.E.,
Harrison M.A.,
FedorkaCray P.J.
Publication year - 2006
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1111/j.1365-2672.2006.03036.x
Subject(s) - antimicrobial , tetracycline , salmonella , salmonella enterica , microbiology and biotechnology , serotype , inoculation , biology , strain (injury) , chlortetracycline , transmission (telecommunications) , antibiotics , bacteria , immunology , engineering , genetics , electrical engineering , anatomy
Abstract Aims: To determine the effect of antimicrobial selective pressure on the transmission of antimicrobial resistant and sensitive strains of Salmonella in poultry. Methods and Results: Eight pens housed 12 broiler chicks each. Two chicks in four of the pens were inoculated with a Salm. Typhimurium strain resistant to 12 antimicrobials (including tetracycline), and two chicks in each of the four other pens were inoculated with a strain sensitive to all antimicrobials tested. Two pens inoculated with each strain were treated with chlortetracycline and two were not. Chicks were killed on day 7 and caeca were cultured for Salmonella . Experiments were performed independently twice. Chicks exposed to pen mates inoculated with the resistant strain and treated with tetracycline were 90% positive for Salmonella ; whereas 60% of chicks given no antimicrobials were positive. Chicks exposed to the sensitive strain were 95% positive with tetracycline treatment and 90% positive without treatment. Conclusions: A multidrug‐resistant Salm. Typhimurium strain had significantly increased transmission when chicks were treated with tetracycline. Transmission of a sensitive strain was not inhibited by antimicrobial selective pressure at recommended therapeutic dose. Significance and Impact of the Study: This study demonstrates that antimicrobial usage may influence the transmission of antimicrobial‐resistant pathogens in poultry.