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Damage to Pseudomonas aeruginosa PAO1 bacteriophage F116 DNA by biocides
Author(s) -
Maillard J.Y.,
Beggs T.S.,
Day M.J.,
Hudson R. A.,
Russell A.D.
Publication year - 1996
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1996.tb03254.x
Subject(s) - peracetic acid , capsid , nucleic acid , pseudomonas aeruginosa , bacteriophage , biocide , microbiology and biotechnology , dna , bacteriophage ms2 , biology , bacterial virus , genome , chemistry , virology , bacteria , virus , gene , biochemistry , escherichia coli , genetics , hydrogen peroxide , organic chemistry
The mechanism of action of biocides against viruses has not been widely studied, although two main targets are viral proteins (capsids, enzymes) and the viral genome. This study was undertaken in order to investigate the efficacy of several disinfectants against the nucleic acid of the Pseudomonas aeruginosa PAO bacteriophage F116. Of all the biocides tested, only peracetic acid affected significantly the phage genome. However, it is not clear whether the nucleic acid was damaged inside the phage capsid or when released into the surrounding medium.