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Minimum inhibitory concentrations of intestinal Escherichia coli from broiler chickens after oral administration of apramycin
Author(s) -
Kobe A.,
Ebrecht A.,
Fries R.
Publication year - 1996
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1996.tb03185.x
Subject(s) - broiler , minimum inhibitory concentration , escherichia coli , biology , antibiotics , microbiology and biotechnology , agar dilution method , veterinary medicine , agar , agar dilution , bacteria , zoology , medicine , biochemistry , genetics , gene
This study describes the influence of apramycin on minimum inhibitory concentrations (MIC) of intestinal Escherichia coli in young broiler chickens, after oral administration of the antibiotic at a dosage equivalent to a prophylactic course of treatment for 10 d. The bacteria were isolated from cloacal swabs and caecal contents. MICs were determined by agar dilution procedures. MIC of apramycin for the investigated strains ranged from 1 μg ml ‐1 to 16 μg ml ‐1 . Strains obtained from undosed birds mainly had MIC values of 1 μg ml ‐1 . MIC values of 8 μg ml ‐1 or more were recorded only among isolates obtained from chickens which had received apramycin. Administration of apramycin resulted in a slight but statistically significant increase in the average MIC. Statistically higher average MICs were recorded among isolates from cloacal swabs 10 d after withdrawal until the end of the experiment. For strains from caecal contents, this was demonstrated only on one sampling occasion, 15 d after withdrawal.