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Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobacter pylori
Author(s) -
Korhonen H.,
Syväoja E.L.,
AholaLuttila H.,
Sivelä S.,
Kopola S.,
Husu J.,
Kosunen T.U.
Publication year - 1995
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1995.tb03112.x
Subject(s) - colostrum , antibody , immunization , helicobacter pylori , lactation , microbiology and biotechnology , immune system , immunology , passive immunity , bovine milk , chemistry , biology , medicine , pregnancy , food science , genetics
Serum and colostrum but not post‐colostral milk from non‐immunized Friesian cows was found highly bactericidal for Helicobacter pylori NCTC 11637. This bactericidal activity was destroyed by heating at 56°C for 30 min and restroed by the addition of fetal calf serum as a source of complement, indicating that the bactericidal effect was probably dependent on an antibody‐complement system. Systemic, serial immunization of non‐lactating, pregnant cows with H. pylori resulted in high specific antibody titres in serum and colostrum. No titres were found in post‐colostral milk, even after booster‐immunization during lactation. Immunization did not enhance the bactericidal activity of serum and colostrum, but increased it in post‐colostral milk. The bactericidal activity was not correlated with titres of specific antibody or with IgG concentrations.