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The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries
Author(s) -
Blondelle Sylvie E.,
Takahashi Ema,
Dinh Kim Thy,
Houghten R.A.
Publication year - 1995
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1995.tb01671.x
Subject(s) - antimicrobial , antimicrobial peptides , in vitro , bacteria , peptide , biological activity , chemistry , biochemistry , antibacterial peptide , biology , combinatorial chemistry , microbiology and biotechnology , antibacterial activity , genetics
S.E. BLONDELLE, E. TAKAHASHI, K.T. DINH AND R.A. HOUGHTEN. 1995. A series of peptides identified through the use of synthetic hexapeptide combinatorial libraries (represented by the formula Ac‐RRWWCO‐NH 2 ) were examined for their antimicrobial activity against five different micro‐organisms. Their toxicity was also evaluated in an in vitro haemolytic assay. The peptides showed activity against the five micro‐organisms, although higher activities were found against Gram‐positive bacteria. Both growth inhibition and cell viability assays were carried out to demonstrate the bactericidal activities of these peptides against two of the micro‐organisms tested. The dimeric cystine forms of these peptides were shown to have biological activities identical to the monomeric forms.