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HM17, a new polyene antifungal antibiotic produced by a new strain of Spirillospora
Author(s) -
Hacène H.,
Kebir K.,
Othmane D. Sid,
Lefebvre G.
Publication year - 1994
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1994.tb04391.x
Subject(s) - polyene , botrytis cinerea , fusarium oxysporum , antifungal , botrytis , strain (injury) , microbiology and biotechnology , antibiotics , fusarium , fungus , broad spectrum , biology , botany , chemistry , biochemistry , combinatorial chemistry , anatomy
H. HACÈNE, K. KEBIR, D. SID OTHMANE AND G. LEFEBVRE. 1994. An antifungal antibiotic (HM17) was obtained from a new isolate classified to the genus Spirillospora on the basis of its chemical and morphological properties. On solid media this antibiotic strongly inhibited the growth of strians of Fusarium oxysporum formae speciales albedinis, Botrytis cinerea, Gaeumaniomyces graminis and several other fungi known to be plant and human pathogens. Antifungal activity in culture collection strains of Spirillospora has not so far been reported. The u.v. absorption spectrum and physico‐chemical characteristics place HM17 in the methylpentaene sub‐group of polyene macrolides. HM17 is different from other known methylpentaenes. This is the first report of polyene production by a Spirillospora.