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Fungicin M4: a narrow spectrum peptide antibiotic from Bacillus licheniformis M‐4
Author(s) -
Lebbadi M.,
Gálvez A.,
Maqueda M.,
MartínezBueno M.,
Valdivia E.
Publication year - 1994
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1994.tb03043.x
Subject(s) - bacillus licheniformis , corynebacterium diphtheriae , microbiology and biotechnology , peptide , corynebacterium glutamicum , sporothrix schenckii , biology , strain (injury) , chemistry , biochemistry , bacteria , bacillus subtilis , diphtheria , anatomy , genetics , gene , vaccination , immunology , sporotrichosis
The strain Bacillus licheniformis M‐4 produces a 3.4 kDa hydrophilic peptide with antifungal activity, named fungicin M4. Analysis of the purified peptide shows that it contains the amino acids Glu (8), Arg (5), Pro (4), Tyr (8), Val (3), Met (2) and Orn (4). Its inhibitory spectrum is restricted to Microsporum canis CECT 2797, Mucor mucedo CECT 2653, Mucor plumbeus CCM F 443, Sporothrix schenckii CECT 2799, Bacillus megaterium and Corynebacterium glutamicum CECT 78. Fungicin M4 exerts biocidal activity on liquid cultures of Sporothrix schenckii CECT 2799.