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In vitro susceptibility of Clostridium perfringens isolated from farm animals to growth‐enhancing antibiotics
Author(s) -
Devriese L.A.,
Daube G.,
Hommez J.,
Haesebrouck F.
Publication year - 1993
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1993.tb03407.x
Subject(s) - virginiamycin , tylosin , clostridium perfringens , salinomycin , bacitracin , microbiology and biotechnology , antibiotics , biology , minimum inhibitory concentration , veterinary medicine , bacteria , medicine , genetics
Minimal inhibitory concentration (MIC) determinations were carried out with seven growth‐enhancing antibiotics against 95 Clostridium perfringens field isolates obtained during 1991 and 1992 from poultry, pigs and calves. All were resistant to 64 μg ml −1 of the bambermycin antibiotic, flavomycin (flavophospholipol) and susceptible to avoparcin (MIC 90 0.25 μg ml −1 ), avilamycin (MIC 90 0.5 μg ml −1 ) and salinomycin (MIC 90 ≤ 0.12 μg ml −1 ). Acquired resistance against bacitracin was detected in some isolates from poultry and bovines and resistance to tylosin and virginiamycin in some strains from all species investigated. Overall, the prevalence of resistance was comparable to the low levels recorded in 1979 in Cl. perfringens isolates from the same animal host species.