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Effect of polysaccharide interactions on antibiotic susceptibility of Pseudomonas aeruginosa
Author(s) -
Allison D.G.,
Matthews M.J.
Publication year - 1992
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1992.tb05009.x
Subject(s) - pseudomonas aeruginosa , tobramycin , ciprofloxacin , microbiology and biotechnology , mucin , cystic fibrosis , antibiotics , chemistry , antimicrobial , pseudomonas , polysaccharide , pseudomonadales , pseudomonadaceae , bacteria , biology , biochemistry , gentamicin , genetics
The relative viscosity of Pseudomonas aeruginosa alginate was shown to increase markedly when combined with mucin, Ca 2+ ions and the exopolysaccharide from Pseudomonas cepacia. The presence of such a heterodisperse polysaccharide solution significantly reduced the diffusion and hence antimicrobial activity of tobramycin and to a lesser extent ciprofloxacin against Ps. aeruginosa by factors of 90 and 2.5‐fold respectively over a 5 h incubation period. The clinical implications of these results are discussed in relation to cystic fibrosis.