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Sequential release of antigens from chloroform‐treated Staphylococcus epidermidis : application towards a possible vaccine
Author(s) -
Ahmad A.,
Clarke S.,
Buchan A.,
Skinner G.R.B.
Publication year - 1990
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1990.tb01562.x
Subject(s) - staphylococcus epidermidis , antigen , microbiology and biotechnology , chloroform , staphylococcus , staphylococcus aureus , bacteria , biology , medicine , chemistry , immunology , chromatography , genetics
A hmad , A., C larke , S., B uchan , A. & S kinner , G.R.B. 1990. Sequential release of antigens from chloroform‐treated Staphylococcus epidermidis : application towards a possible vaccine. Journal of Applied Bacteriology 69 , 676–685. This study describes the properties of two potential Staphylococcus epidermidis vaccines prepared by chloroform treatment of bacteria and release of antigen from these chloroform‐treated organisms. Both vaccines were antigenic on testing with homologous hyperimmune serum and induced immune reactivity in immunized rabbits. There was protective efficacy in mice against intraperitoneal challenge by Staph, epidermidis .