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Effect of minocycline on subgingival plaque bacteria
Author(s) -
Wilson M.,
O'Connor B.,
Newman H.N.
Publication year - 1990
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1990.tb01513.x
Subject(s) - minocycline , microbiology and biotechnology , dental plaque , bacteria , dentistry , medicine , biology , antibiotics , genetics
The effects of minocycline on subgingival plaque samples from patients with chronic periodontitis were investigated in vitro. Minocycline concentrations as low as 1.0 μg/ml inhibited 95.7% of the cultivable bacteria in the samples but 256 μg/ml was necessary to inhibit all of the cultivable bacteria in the samples. Although up to 99.9% of bacteria in the plaque samples were killed by a 6 h exposure to 8.0 μg/ml of minocycline, large numbers of viable bacteria remained. These results imply that adequate reductions in the numbers of viable subgingival plaque bacteria are unlikely to occur after exposure to minocycline at concentrations attainable in gin‐gival crevicular fluid after systemic administration.