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Performance profiles of topical antimicrobials in vitro
Author(s) -
Hart A. P.,
McColl K.,
Thomas C.,
Orr N. A.
Publication year - 1989
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1989.tb02501.x
Subject(s) - antimicrobial , agar , in vitro , agar diffusion test , microbiology and biotechnology , chemistry , biology , bacteria , antibacterial activity , biochemistry , genetics
The in‐vitro efficacy of commercially available topical antimicrobial products against control strains and those from clinical material are compared with an agar diffusion model. The MICs of the constituent antimicrobial compounds have been determined for the same organisms. Plotting the inhibition zone diameters produced by the topical products against the log 10 MICs of their constituent antimicrobial compound(s) gives overall product performance profiles for a range of organisms. These profiles confirm that the formulation of a topical product clearly modifies the response obtained with a specific antimicrobial compound.