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Antibody response to bacterial antigens covalently bound to biodegradable polymerized serum albumin beads
Author(s) -
Lanchein C.,
Newman J.F.E.
Publication year - 1987
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1987.tb04866.x
Subject(s) - antigen , chemistry , adjuvant , covalent bond , antibody , albumin , klebsiella pneumoniae , microbiology and biotechnology , bovine serum albumin , serum albumin , biochemistry , immunology , biology , escherichia coli , organic chemistry , gene
Model vaccines have been made by covalently linking Clostridium botulinum type D toxin and Klebsiella pneumoniae capsular polysaccharide antigen to polymerized rabbit serum albumin beads. When injected into rabbits these bead vaccines induced an enhanced production of specific humoral antibody without causing adverse reactions. The adjuvant effect is due to a slow release from the bead structure and offers an alternative to oil emulsions and mineral salt adsorbents.