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Bactericidal properties of an organic N‐chloramine formed in situ
Author(s) -
Elder Elisabeth D.,
Worley S. D.,
Williams D. E.
Publication year - 1987
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1987.tb02677.x
Subject(s) - disinfectant , chloramine , chlorine , calcium hypochlorite , in situ , chloramine t , chemistry , hypochlorite , nuclear chemistry , bacteria , sodium hypochlorite , medicinal chemistry , inorganic chemistry , organic chemistry , biology , genetics
Agent I (3‐chloro‐4,4‐dimethyl‐2‐oxazolidinone) formed in situ was compared with pre‐formed agent I as a disinfectant against Staphylococcus aureus. In situ formation involved combining the non‐chlorinated oxazolidinone precursor with calcium hypochlorite to form 5 and 10 mg/l total chlorine concentrations of agent I. The variables included in the study were temperature, pH and concentration. Overall the bacteria were killed more rapidly at 22° than at 4°C. The in situ formation appeared to occur most rapidly at pH 7˙0, slightly slower at pH 9˙5, and very slowly at pH 4˙5 as evidenced by the presence of residual free chlorine. In the in situ experimental runs the 5 and 10 mg/l concentrations were equally effective in obtaining a six log decline in cfu/ml. This study indicates the potential for using the organic N‐chloramine as a general purpose disinfectant while omitting the laboratory synthesis of the final product.