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Inhibition of hyphal development and kill of Candida albicans blastospores by noxythiolin in vitro
Author(s) -
Gorman S. P.,
Mccafferty D. F.,
Woolfson A. D.,
Anderson L.
Publication year - 1986
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1986.tb01739.x
Subject(s) - hypha , candida albicans , mycelium , microbiology and biotechnology , germination , germ tube , corpus albicans , in vitro , population , strain (injury) , biology , chemistry , botany , biochemistry , medicine , environmental health , anatomy
The cidal activity of the antimicrobial agent, noxythiolin, was investigated against a laboratory strain and a fresh isolate of Candida albicans. The order of resistance to noxythiolin was hyphal form (isolate) ≥ 25°C‐grown blastospores (isolate) ≥ 37°C‐grown blastospores (isolate) > laboratory strain blastospores. Noxythiolin activity was superior to that of ‘equivalent’ formaldehyde concentrations. Mycelial transformation in C. albicans was examined by light and scanning electron microscopy and measured in terms of percentage germination and hyphal extension. Noxythiolin, 2·5%, in contact for 30 min prevented germination of the blastospore population whereas the decomposition products, formaldehyde and N‐methylthiourea, showed no appreciable effect in the expected concentrations. The implications of these results are discussed in relation to the observed clinical efficacy of noxythiolin.